Approfondimenti su: Medicina ultima settimana e Medicina ultimo mese
Categoria: Medicina | Venerdì 02 Settembre 2022, Ventok
Product name: Ventok
Common name: Venetoclax.
Indications
Venetoclax is a BCL-2 inhibitor suitable for those with 17p deficiency through FDA approved testing
Treatment of patients with chronic lymphocytic leukemia (CLL) who have received at least one previous treatment.
This indication is approved based on the overall response rate under accelerated approval. Continued approval of this indication may take
Depends on the description and confirmation of clinical benefits in confirmatory trials.
Dose and administration method
Method of administration
Venetoclax is initially treated at 20 mg once a day for 7 days, followed by a weekly incremental dose The medication schedule is to the recommended daily dose of 400mg.
Venetoclax tablets should be taken orally with food and water once a day. Do not chew, crush or break the tablet.
Prevent tumor lysis syndrome.
Dosage specifications
Tablets, 10mg, 50mg, 100mg.
Contraindications: strong inhibitors of Venetoclax and CYP3A are contraindicated in the initial and increasing dose stages use simultaneously.
Warnings and Precautions
Tumor Lysis Syndrome (TLS): Predicting TLS: Assess risk in all patients. Anti-hyperuric acid
Pre-administration of antihypermic drugs and ensure proper hydration. When the overall risk increases, stronger measures (intravenous hydration,
Frequent surveillance, hospitalization).
Neutropenia: monitor blood cell count and signs of infection, and treat according to clinically appropriate methods.
Vaccination: Do not give live attenuated vaccine before, during, or after Venetoclax treatment.
Embryo-fetal toxicity: may cause embryo-fetal harm. Advise women with reproductive potential At risk, and use effective contraception during treatment.
Adverse reactions
The most common adverse reactions (≥20%) include: neutropenia, diarrhea, nausea, anemia, upper
(Please read this notice carefully and take the medicine according to this notice or under the guidance of a doctor)
Respiratory tract infections, thrombocytopenia, and fatigue.
Storage method
The storage environment is below 30°C (86°F).